Treatment of atopic dermatitis in acute periodof children presupposes hospitalization, especially in cases of severe disease. A prerequisite is also the identification and exclusion of contact with causally significant allergens. In this case, a hypoallergenic diet is prescribed. The products of allergic reaction and allergens are eliminated from the body. The following activities are designated for this purpose:
- Cleansing enema;
- Alkaline drink (abundant);
- carrying out enterosorption through the use of different sorbents (Enterodez, activated carbon, Lactofiltrum, Enterosgel and others), taking into account certain clinical manifestations.
Such measures allow quite fasteliminate acute manifestations that accompany skin dermatitis. Treatment is also advisable to carry out with the use of polyenzymatic drugs. They include "Creon", "Mezim-forte", "Panzinorm", "Pankurmen", "Enzistal" and others. Thus, food sensitization decreases. Selection of the enzyme preparation is carried out taking into account clinical symptoms.
Treatment of atopic dermatitis in an acute period inchildren includes such an important stage as the appointment of antihistamines. Today, in medical practice, the first generation of drugs, because of the need to create their increased concentrations in order to obtain therapeutic results and the presence of side effects, have very limited application. To eliminate the acute manifestations that accompany atopic dermatitis, treatment is prescribed by parenteral administration of antihistamines. Tavegil is recommended for these purposes. This drug has a longer lasting effect. Elimination of severe itching is advisable to produce a short course with the use of first-generation drugs that have a sedative effect. ("Suprastin", "Peritol"). After the expiration of two to three days, a second-generation antihistamine medication is recommended.
The above preparations have a highspecificity and relationship with H1-receptors. In addition, antihistamines do not have an M-holinotic effect, hypnotic and sedative effect, acting on the late and early phases of an allergy, do not provoke the development of tachyphylaxis. The clinical efficacy of all drugs of this class in therapeutic dosages is approximately identical. However, in accordance with the safety of use, the preferred drug may become "Loratadine."
Treatment of atopic dermatitis in combination withallergic rhinitis or bronchial asthma in children suggests the appointment of antihistamines of the third generation. The drugs do not have metabolites, as well as cardiotoxic and sedative properties. Such medicines include Desloratadine and Fexofenadine. The first has a pronounced antihistamine effect, significantly exceeding other known means. In addition, Desloratadine also has an anti-inflammatory effect, in other words, it is able to block the release of mast cells from histamine, inhibit the migration of eosinophils and the synthesis of cytokines. The drug also quickly and effectively eliminates manifestations, in particular, nasal obstruction against allergic rhinitis, reduces night attacks and cough with bronchial asthma.
Treatment of atopic dermatitis in children withexpressed violations of hemostasis in the acute period is recommended to be performed with the use of infusion therapy. In this case, vascular drugs, disaggregants and anticoagulants are used to eliminate the phenomena of thrombovasculitis.
In the absence of effect from the therapy, hormonal glucocorticosteroid treatment is indicated.
