The drug "Ceftazidime" belongs to the groupcephalosporin antibiotics of the third generation. The drug has a fairly wide spectrum of action. The drug has bactericidal activity, due to inhibition of bacterial cell wall synthesis. The agent acts on anaerobes, gram-negative, aerobes and gram-positive bacteria. The drug is active against strains resistant to methicillin, ampicillin, cephalosporins and aminoglycosides. The drug binds to proteins by 10-17%, it is well distributed in liquids and tissues of the body. The medicine is able to penetrate the placental barrier, it is found in milk. Therapeutic concentrations of the agent reach in the cerebrospinal fluid. An insignificant amount of the drug penetrates into the bile. Isolation from the body is carried out in an unchanged form with urine (predominantly).
Medication "Ceftazidime". Instructions for use. Indications
The medicine is prescribed for infectious and inflammatory pathologies of organs and tissues provoked by pathogens showing sensitivity to it.
The remedy is not recommended for intolerance to itcomponents, as well as other cephalosporins. The administration of the drug to pregnant or lactating patients is strictly according to the indications. Caution should be observed in the treatment of patients with disorders of kidneys, newborns. In persons who are intolerant of penicillins, it is likely the development of allergy to cephalosporin antibiotics. Correction of dosage may be necessary while using the agent with aminoglycosides and loop diuretics.
Means of "Ceftazidime". Directions for use: adverse reactions
Medication can provoke angioedema,pseudomembranous colitis, vomiting, candidiasis, hypoprothrombinemia. On the basis of therapy, sometimes there is diarrhea, nausea, interstitial nephritis, tenderness in the site of injection, phlebitis. To the negative consequences of the use of "Ceftazidime" in elevated doses, the instructions for use refer to changes in the pattern of peripheral blood. In particular, there is a possibility of neutropenia, hemolytic anemia, leukopenia, thrombocytopenia.
Cefetazidim agentrecommends injecting intravenously or intramuscularly. For adults, the dosage is 0.5-2 g every eight or twelve hours. Maximum per day is allowed not more than 6 gr. Children from 1 month to 12 years of age are prescribed 30-50 mg / kg / day. The frequency of administration is no more than three times a day. Children under the age of one month are prescribed 30 mg / kg / day. The amount of the drug is divided into two administrations.
Medication "Ceftazidime". Instructions for use. Price. additional information
The cost of the medicine is within a hundred rubles.When combined with a number of drugs that have a nephrotoxic effect, the drug "Ceftazidim" potentiates this activity. Use the medicine only if prescribed by a doctor.