Гипертония, ишемическая болезнь сердца, Angina pectoris today are very common health problems of modern man. And such diseases are significantly "younger" - if earlier they suffered from patients of adulthood, today even young people are diagnosed with ischemic heart disease and hypertension. To treat these health problems, the pharmaceutical industry produces a variety of medicines, one of which is Amlotop. Instructions for use, reviews about it will be discussed below.
For the drug "Amlotop" in the instructions foruse, invested by the manufacturer in each package of the drug, denotes a pharmaceutical accessory - a blocker of "slow" calcium channels. This is a fairly extensive group of drugs, including several positions of active substances that have a similar effect, but differ in their effect on heart rate, pharmacokinetics, tissue susceptibility.
Micronutrients play an important role in the bodyrights. So, for example, when penetrating tissue cells, calcium ions activate such processes of bioenergetics as protein phosphorylation (one of the stages of biosynthesis), the metabolism of ATP (adenosine triphosphate acid - a source of energy for metabolic and metabolic processes in the body) in cAMP (cyclic adenosine monophosphate, It plays the role of an intermediary between some hormones and tissue cells). But, like any other components, these substances should be in the cells in a certain amount. If, for some reason, there is an increase in their concentration, the processes of cellular metabolism, require an increase in the concentration of oxygen, which can lead to destructive changes. Transfer of calcium ions Ca2+ (transmembrane transfer) occurs throughspecial calcium channels, which are quite complex and diverse. Today, scientists have found that calcium channels that have a complex structure of transmembrane proteins can be divided into two types:
These chemical-physical processes play the most importantfunction in the cellular exchange. Also, calcium channels are divided into types that differ from each other in some properties. They are designated by letter indices - L, N, P, Q, R, T.
L-type channels received their name fromEnglish words long-lasting - long-lived, larde - large, depending on the conductivity - they are slowly activated when the cell membrane is depolarized, which determines the input of Ca2+ into the cell and the formation of a slow calcium potential.
L-type channels are found in cardiomyocytes, incells of smooth muscles of arterial vessels and most internal organs, as well as in cells of the conduction system of the heart, in skeletal muscles and in platelets. It is to a group of drugs that delay the work of these intercellular adapters that the "Amlotop" drug and its analogues belong.
Препарат "Амлотоп" выпускается несколькими pharmaceutical companies. But the form of its release is only one - in the form of tablets that, however, have different contents of the active component. It can be 5 or 10 mg in one unit - a tablet. The drug "Amlotop", its analogs, issued in different dosage forms, have antianginal (relieving angina and attack) and hypotensive (blood pressure lowering) effect. A group of drugs that have such an effect is very extensive. But the question of how to treat which of them for a particular patient can be solved by the treating specialist taking into account many circumstances. Accept "Amlotop" without consulting a doctor, on the advice of friends is strictly prohibited!
One of the widely used in medicalpractice of antihypertensive drugs is the drug "Amlotop". In the instruction to it active substance - derivative amlodipine - besylate is designated. As additional components are used:
These substances have no therapeutic role, performing only form-building functions.
Tablets "Amlotop" in both 5 and 10 mg haverounded shape, they are flat, with chamfered edges at the edges. Each unit of the drug on one side is provided with a median risk for the convenience of dividing the tablet. The medicine is packed in 10 or 30 pieces in blister cells with an aluminum protective film. Plates with tablets of 2, 3, 5, 10 pieces are stacked in cardboard packs.
As noted, the instructions for use"Amlotopa" indicates the active substance - amlodipine besylate. It is a crystalline powder of white color, practically insoluble in water. It has antianginal, hypotensive and vasodilating properties. Such a spectrum of activity is due to the fact that it blocks calcium channels, reduces the activity of the calcium ion transfer through the cell membrane into the cell. For amlodipine, it is characteristic to work in smooth muscle cells of blood vessels, although it works somewhat worse in cardiomyocytes. This substance expands coronary and peripheral arteries and arterioles, which causes its antianginal action. Due to this effect, the drug reduces the severity of myocardial ischemia in angina pectoris, lowers the peripheral resistance of blood vessels and the need for myocardium in oxygen, prevents the spasms of coronary arteries, including those caused by smoking, which reduces the load on the heart muscle.
Hypotensive effect of the drug "Amlotop"is based on its vasodilating (relaxing) effect on smooth muscle vessels. For those who suffer from stable angina, the use of the drug in a single daily dosage makes it possible to strengthen immunity to physical exertion. Also, the drug reduces the potential risk of developing angina attacks and ischemic depression, which has a direct impact on the use of drugs nitroglycerin and other nitrates, reducing their dose and the number of applications.
The drug Amlotop reducesthe level of myocardial hypertrophy of the left ventricle, but does not affect its contractility and conductivity, does not cause an increase in the heart rate at the reflex level, inhibits aggregation, that is, gluing together, platelets. Also, the drug positively affects the work of the kidneys, potentiating the rate of glomerular filtration and exerting some natriuretic effect. The drug "Amlotop" was also used for nephropathy associated with diabetes.
This medicine does not affect the metabolism in any waybody, and therefore it can be taken in patients with diabetes mellitus, bronchial asthma, gout. Also, the administration of this drug does not affect the increased risk of death for patients with a diagnosis of chronic heart failure III-IV functional class, but with the same disease V-VI FC is not ischemic origin, there is a potential for the development of pulmonary edema.
In the instructions for use of the drug "Amlotop" lists the diseases and conditions under which this drug is prescribed:
This drug can be used as amono-means, and in the complex therapy of these diseases. Appoint it to use can only the attending physician, taking into account all the necessary nuances - anamnesis, concomitant diseases, state of health.
One of the drugs that provide blockingaction on calcium channels, - "Amlotop". The instructions for its use indicate that the tablets are taken orally. The active ingredient amlodipine is well absorbed in the gastrointestinal tract, while its bioavailability is from 64 to 80%.
In the patient's body, the active component of the drugis distributed mainly in tissues, and not in blood. Metabolizes amlodipine in the liver, and metabolites do not have significant pharmacological activity. The half-life period is about 45 hours. In elderly patients older than 65 years, this time is somewhat longer - about 65 hours, but this figure has no clinical significance. The same factor applies to patients suffering from renal and / or liver failure. From the body, the drug "Amlotop" is excreted mainly by the kidneys, 10% being excreted unchanged. The rest is excreted with bile through the intestine. The doctor who prescribes "Amlutop" for use should remember that the active substance of the drug penetrates the blood-brain barrier. If necessary, it is also necessary to take into account that the medicine is not removed from the body during hemodialysis.
Many people suffering from coronary heart disease, angina pectoris use in the outpatient treatment pills "Amlotop". The instructions for use of this medication are contraindications:
Also, the drug can not be taken in childrenage - inclusive up to 18 years due to the lack of clinical studies. Not recommended for use of this drug for pregnant and lactating women. The drug is prescribed with extreme caution in hypertrophic cardiomyopathy, non-ischemic chronic heart failure of the III-IV functional class, impaired active functional of the liver, mitral stenosis, in the syndrome of weakness of the sinus node, expressed tachycardia and bradycardia, acute myocardial infarction.
The use of "Amlotop" is possible only on the recommendation of a doctor. Like any other medicine, it can cause side effects, including:
In the instructions for use for tablets "Amlotop" states that they are taken once, regardless of the time of the meal. Tablets must be washed down with plenty of plain water.
Usually start with 5 mg, then, ifIt is necessary to increase to 10 mg per day, it is considered the maximum dose. Such a change in dosage is carried out 1-2 weeks after the start of treatment by Amlotop. If you need to quickly increase the dose of this drug, then it should be done only under the supervision of a specialist. It is impossible to change the number of pills at a time, and also to take this medicine more than once a day!
If a patient receives treatment with antihypertensive drugs, the initial daily dose of Amlotop may be 2.5 mg, since the effect of lowering blood pressure will be added up.
Therapy with this medicine in relation to special groups of people with underweight, short stature, advanced age, and problems with the functioning of the liver is carried out individually.
Many patients note the effectiveness of the drug "Amlotop". The instructions for use of this medication indicate that an overdose of the active ingredient may cause:
Be sure to read the instructions forapplication "Amlotop". At what pressure can it be and can not be taken? The manufacturer of the drug in the instructions to him indicates that the drug can not be used with systolic blood pressure below 90 mm Hg. Art. It is also necessary to take into account the compatibility of the active ingredient with other drugs that the patient takes.
This medicine can safely be used withdrugs such as alpha-blockers, beta-blockers, thiazide diuretics, or angiotensin-converting enzyme inhibitors (ACE), nonsteroidal anti-inflammatory drugs, including indomethacin, antibiotics, hypoglycemic agents. It is important to remember that calcium supplements can significantly reduce the activity of the calcium channel blocker amlodipine. Neuroleptic drugs with complex therapy with Amlotop can enhance its hypotensive effect. If the patient is taking this drug and he needs antiviral treatment, then an increase in the concentration of amlodipine in the blood should be taken into account and its single dosage should be reduced.
The use of the drug "Amlotop" requires the patient to adhere to the recommendations of the doctor in terms of dosing and administration.
Research on the treatment of children and breastfeedingwomen were not conducted, therefore the possibility of danger or its effectiveness for these categories of patients is not known. This medicine can be prescribed to a pregnant woman only if the risk to the fetus is minimal compared to the benefit to the mother. It is better to choose, if necessary, another drug. The drug in a single application does not have a negative impact on the concentration of attention, but with a course treatment it is not recommended to drive and work that require high concentration of attention. Also, long-term treatment with this drug requires not only the highest possible observance of dental and oral hygiene, but also regular visits to the dentist, in time to eliminate the negative manifestation of its action on the oral cavity, timely detect gingival hyperplasia, their bleeding and take measures to preserve the health of teeth and gums .
You can buy medicine "Amlotop" and its analoguesonly by prescription at the pharmacy. It is stored at room temperature, storage space must be chosen without access to direct sunlight. The expiration date of the drug from the date of its manufacture is 3 years; if this period has ended, the drug cannot be used in therapy. The drug has an affordable cost - from 70 to 170 rubles per pack of 30 tablets, depending on the amount of the active substance - 5 or 10 mg.
All necessary information for the doctor and patient.contains about the drug "Amlotop" instructions for use. Analogs can be found in any pharmacy. These are such means as "Normodipin", "Tenox", "Amlodak", "Norvask". Also in pharmacy chains you can buy a generic "Amlotopa" - this drug will be named by the name of the active ingredient - "Amlodipine", and some pharmaceutical companies add their own name to this name, for example, "Amlodipine - Zentiva".
Врач может назначить к применению лекарственное a drug with the same pharmacological activity, but having another substance as an active ingredient. For example, verapamil, lekranidipil, cinnarizine, working in the drugs under the names "Verogalid", "Lerkamen", "Stugeron". The correct choice of drug, the duration and fullness of the course of therapy, determined by the attending specialist, will help to cope with the disease qualitatively, without side effects.
Amlotop tablets are often prescribed to patientswith increased pressure and risk of myocardial infarction. Doctors speak about this drug as a fairly effective means capable of exerting the necessary effect even with a single use. For the drug "Amlotop" instructions for use contains important information for the patient, in particular, the dose of administration. In some cases, it can be adjusted by a doctor according to the patient’s history and the course of the disease. Doctors note the high effectiveness of this tool to normalize strokes, prevent the development of hypertension and reduce the potential risk of myocardial infarction. From the point of view of specialists, the occurrence of side effects is most often noted in the form of edema of the lower extremities and dizziness. The remaining undesirable effects of the drug occur very rarely.
The drug "Amlotop" receives feedback from patients,mostly grateful. Those who praise the medicine note that it is convenient to use it once a day, its effectiveness to normalize pressure, relieve symptoms of angina and coronary heart disease. Some are upset by the appearance of side effects - edema in the legs, dizziness, headaches. Some patients, because of the vivid manifestation of such an unnecessary action of the drug, were forced to abandon it, although the price and the Russian production are satisfied with almost everyone. Many patients note that they use the drug only to lower the pressure, although some thank the remedy for help with a course course, a rather long intake.
For the drug "Amlotop" instructionapplication contains important information that must be known not only to the specialist, but also to the patient, who accepts it for certain therapeutic purposes. Again, you can take it only on doctor's prescription!
