Для чего «Ибупрофен» назначают пациентам?We will tell you about this in the presented article. From it you will learn about the form in which the said remedy is made, how and in what dosage it should be taken, and so on.
How is Ibuprofen produced? Instructions for use, reviews of experts report that this drug is produced in various forms.
Для чего «Ибупрофен» используют в медицинской practice? According to the instructions, this medication is a nonsteroidal anti-inflammatory agent. It can have anti-inflammatory, antipyretic and analgesic effects. Experts say that this tool indiscriminately blocks TSOG2 and TSOG1.
The principle of action of ibuprofen is to slow down the synthesis of prostaglandins, that is, mediators of inflammation, pain and hyperthermic reaction.
What pharmacokinetic indicators do Ibuprofen tablets have? The use of oral forms of the drug provides high and rapid absorption from the gastrointestinal tract.
The highest concentration of ibuprofen in plasma is observed in 120-240 minutes after its administration. Communication with plasma proteins is more than 90%, and the half-life is 2 hours.
Ibuprofen (suspension and tablets) slowly penetrates the joints. Its active substance is retained in the synovial tissue. This provides her with large concentrations of the active ingredient.
After absorption, approximately 60% of the inactive R-form of the drug is transformed into the active S-form.
This medication is metabolized. It is derived through the kidneys (unchanged), as well as along with the bile.
What can Ibuprofen be prescribed to patients for? According to the instructions, this drug has the following indications for use:
What other purposes can be usedIbuprofen? What are these pills prescribed for patients? Doctors claim that this drug is actively used for symptomatic therapy. It reduces inflammation and pain well and fairly quickly (only at the time of use), but does not affect the progression of the disease.
For what Ibuprofen is used by patients, we told above. With regard to contraindications, then they include the following patient's condition:
What other contraindications are there for the drug?Ibuprofen? Syrup for children is not recommended to give babies up to 3 months, and other forms of medication - up to 6 years. Also, this medicine should not be used during pregnancy.
What are the conditions with a specialcaution to prescribe the drug "ibuprofen"? Application (reviews of this tool will be presented below) of this drug in the elderly, as well as people with heart failure, hypertension, arterial and coronary heart disease should be strictly controlled by a doctor.
Also with extreme caution, this medicineprescribed for cerebrovascular diseases, dyslipidemia, diabetes, arterial diseases (peripheral), smoking, enteritis, regular alcohol consumption, liver cirrhosis, gastritis, nephrotic syndrome, hyperbilirubinemia, colitis, blood diseases of unknown origin and during breastfeeding.
Ways of using this drug depend on its forms of release.
What dosage is ibuprofen for children?Instructions for use states that, in relation to the tablets, the syrup acts much faster. Shake the vial thoroughly before using this form. The dosage of this medication should be determined only by a pediatrician, depending on the condition of the patient.
Suppositories "Ibuprofen" created specifically forinfants They are used rectally and begin to act after 30 minutes. With febrile or pain syndrome, a single dose of this medication is 5-10 mg per 1 kg of child weight. Apply candles preferably with an interval of 6-8 hours.
How should Ibuprofen ointment be used?The gel, a strip of 1.5 cm, is applied to the lesion with light massaging movements. It should be charming to avoid getting the drug on the mucous membranes and open wounds. Otherwise, the medication should be immediately rinsed with warm water.
Are ibuprofen pills harmful to children? Instructions for use states that it is undesirable to give this form of the drug to children under 6 years old.
Take this medication in betweenbetween meals. Usually it is prescribed in the amount of 5-10 mg per 1 kg of human weight three times a day. In this case, the daily dose should not exceed 20 mg per kg.
In rheumatoid arthritis, as well as other diseases of the joints, the drug is prescribed in the amount of 40 mg / kg (but not more).
When taking higher doses of the drugThe patient may develop the following symptoms: nausea, lethargy, abdominal pain, drowsiness, vomiting, tinnitus, depression, metabolic acidosis, headache, acute renal failure, coma, bradycardia, low blood pressure, atrial fibrillation, respiratory failure and tachycardia .
Treatment - urgent gastric lavage (within 60 minutes after overdose), taking activated carbon, alkaline drinking and forced diuresis.
Does the occurrence of adverse reactionsdrug "ibuprofen"? Topical gel never causes undesirable effects. As for the oral forms of the drug, they can cause the following phenomena:
It should also be noted that taking this drug may cause changes in the following laboratory parameters:
If such reactions appear, you should immediately stop taking the medication and consult a doctor.
Treatment with the Ibuprofen medication should be carried out in a minimum dose, which will show maximum therapeutic efficacy. In this case, the course of therapy should be short.
If treatment is carried out for a long time, then control of the kidneys and liver, as well as peripheral blood picture, is required.
When signs of gastropathy appearcareful monitoring of the patient's condition. It should include an esophagogastroduodenoscopy, as well as an analysis of feces for occult blood and a general blood test (in order to determine hemoglobin).
It is extremely undesirable to combine the drug "Ibuprofen" with acetylsalicylic acid and other NSAIDs. This is due to the fact that it can reduce the anti-inflammatory and antiplatelet effects of these agents.
With the simultaneous administration of the medication in question with thrombolytic and anticoagulant drugs, the risk of bleeding increases.
Cefaperazone, Cefamandol, valproic acid, Cefotetan and Plicamycin increase the likelihood of hypoprothrombinemia.
Drugs that block tubular secretion reduce excretion and increase the plasma concentration of Ibuprofen.
The medication in question worsens the effect of uricosuric agents, enhances the effects of indirect anticoagulants, fibrinolytics and antiplatelet agents.
The drug "Ibuprofen" is very popular among patients. It is positioned as a highly effective anti-inflammatory drug that has many forms of release.
According to patient reviews, this medicationbegins to act very quickly. It relieves even the most severe pains in the joints and muscles, and also eliminates headaches and inflammations of various origins.
The only negative of this medicine isthe presence of a large number of side effects and contraindications. According to patient reviews, the Ibuprofen preparation often causes stomach pain, nausea, dizziness and vomiting, and also causes ulcers and erosion in the digestive tract. Therefore, it is recommended to use this medication in minimum dosages, as well as for a short time. This is the only way you can eliminate pain syndromes and at the same time not experience any adverse reactions.
