Already for a long time it became known that the mainmechanism of development of adaptability of various kinds of bacteria to antibiotics are β-lactamases and their products. They very effectively contribute to the destruction of the protective rings of antibiotics and practically nullify their therapeutic effect. To overcome this negative effect, practically chemical compounds that deactivate β-lactamases were developed, first of all, clavulanic acid, preparations of sulbactam and tazobactam.
These compounds are included as elements incomposition of so-called inhibitor-protected penicillins - combined medicines, which include a penicillin antibiotic. Widely known examples of such drugs are ampicillin-sulbactam, amoxicillin, ticarcillin and others making up this group of penicillins. Their use is also effective because they can act as part of a wide variety of cephalosporin combinations of the third generation, while the effectiveness of the active substance remains at a high level.
В ходе различных сочетаний, которые используются in a number of modern medicines, which include antibiotics and β-lactamase inhibitors, the primary activity of penicillins is regenerated, and they almost completely restore their therapeutic effectiveness in fighting most of the currently known staphylococci, anaerobes and gram-negative bacteria. In addition, in such drugs, their antimicrobial spectrum is expanding. These include the drug ampicillin / sulbactam, which, depending on the manufacturer, can still be produced under the names Unazin or Sulacillin.
This medicine includes ampicillin andsulbactam, which are present in a 2: 1 ratio. As indicated in the instructions for use, ampicillin and sulbactam in this preparation, in addition to actually blocking β-lactamases, have quite pronounced activity against Neisseria and Acinetobacter.
As a rule, for internal reception is appointeda drug sultamitsillin, which includes sulbactam and ampicillin. Tablets on intake are absorbed into the body. Then there is a hydrolysis reaction and a joint action of the drug ampicillin and sulbactam, which provides an increase in the bioavailability of ampicillin even above the level that is achieved by taking an equal dose of traditional ampicillin.
The spectrum of this activity is quite wide.drug product. Therefore, the use of the drug is the most shown for infections of bacterial origin of VDP, sinusitis of various forms and etiology. The drug is prescribed for diseases of the lower respiratory tract: chronic bronchitis, pneumonia.
Как сообщает инструкция по применению, ампициллин Sulbactam is effective in the treatment of intra-abdominal and various forms of pelvic infections, including infections of soft tissues, bone and joint infections, sepsis.
The drug ampicillin with sulbactam is significantly more effective compared to amoxicillin / clavulanate in the treatment of infections that are initiated by acinetobacter.
The dosage of the drug is determined by the instructions forapplication. ampicillin is administered orally, for adults the dose is 0.375-0.75 grams, regardless of the meal, twice a day, if the disease is mild. In more severe forms, the use of medication by 1.5-3.0 grams per day, if the severity increases, the dose can be increased to 6.0 grams.
For children, the drug is prescribed in calculated doses, about 50 micrograms per day per kilogram of child's weight. Reception is carried out for two times.
Forms of release and administration of the drugdescribes in detail the instructions for use. ampicillin can also be taken, in addition to tablets, in the form of a powder used to prepare a special suspension (when taken orally). Provided and the use of the drug in the form of injections, for this it is produced in powder form. The solvent is included with the product in the same package.
