/ / Salmonella typhimurium - causative agent, diagnosis, treatment

Salmonella typhimurium - pathogen, diagnosis, treatment

Salmonella typhimurium bacterium is known inmedicine like Salmonella enterica serovar typhimurium. It is a Gram-negative, rod-shaped bacterium with flagella (violet hair-like structures) through which this microorganism moves.

Named bacterium - the main cause of food poisoning (salmonellosis) in humans. It is most often infected with pork, poultry, eggs. Pets can also transmit it.

How are Salmonella classified?

salmonella typhimurium laboratory diagnostics

So, we are interested in salmonella typhimurium - the causative agent of such a dangerous disease like salmonellosis. The salmonella enterica species has 6 subspecies:

  • enterica;
  • salamae;
  • arizonae;
  • diarizonae;
  • houtenae;
  • indica.

The salmonella enterica enterica subspecies includes the following serogroups:

  • A (paratyphi A).
  • B (derby, typhimurium, agona, heidelberg).
  • C (cholerae suis, newport, muenchen, virchowinfantis).
  • D (dublin, enteritidis, rostock, sendai, typhi).
  • E (anatum).

Salmonella typhimurium (S. typhimurium)

salmonella typhimurium pathogen

The enterica species is considered pathogenic for humans and animals, as well as birds, but only a few of them are most significant for humans. And most cases of salmonellosis occur in S. typhimurium.

Many strains of Salmonella are resistant to modernantibiotics, and therefore spread throughout the world. So, nosocomial salmonellosis is a serious problem at present. And in 80% of cases, the causative agent of nosocomial (nosocomial) salmonellosis is S. typhimurium.

Pathogenicity factors

The course and danger of the disease cause the following pathogenicity factors:

  • Flagella provides rapid movement of the microorganism.
  • The bacterium capsule is protected from phagocytes. And because of the inferiority of phagocytosis, sepsis develops.

salmonella typhoimurium treatment

  • The peculiarity of the invasion makes its penetration unobstructed into deep-lying tissues.
  • Due to good adhesion (attachment), provided by fibrils, pectins, LP-saccharide complex, the bacterium is retained in the body.
  • Exotoxins (products of its vital activity) form diarrhea with further dehydration, rapid vascular permeability.
  • Endotoxin stands out against the background of destructivephagocytosis. It is a lipopolysaccharide complex that forms intoxication. Platelet aggregation in small capillaries leads to inflammation, DIC is observed. And the secretion of Na and Cl leads to a reduction of smooth muscles and increased intestinal motility.

How resistant are bacteria?

Salmonella typhimurium are resistant to various environmental factors:

  1. Three months, they are stored at room temperature household items.
  2. Four years are stored in dry animal feces.
  3. Five months - in water, half a year - in dairy products and meat, on an eggshell - up to a month.
  4. Death occurs only at 100 ° C.In meat products, resistance to heat increases (a pound of meat must be boiled for two hours, only after that it will be safe). With the help of pickles and smoked salmonella does not kill.
  5. This pathogen can withstand temperatures as low as -80 ° C.
  6. It is UV resistant.
  7. Disinfectant is required to withstand 20 minutes to destroy the bacterium.

Outbreaks of the incidence of salmonellosis occur in the summer, more often diagnosed in young children due to the imperfections of their immune system.

Патология передается алиментарным путем, также contact and contact household. By the way, it is important when eating eggs to pay attention to the type of protein and yolk. When cloudy, hemorrhaging, rotten smell, the egg is most likely infected. It needs to be thrown away, pour chlorine onto the dishes, and process the hands with them. Soap in these cases does not help.

Winter outbreaks, high lethality and contact-household transmission mechanism occur due to antibiotic resistance and due to the fact that food supply is centralized.

The incubation period

The incubation period lasts from six hours to eight days, but most often the first symptoms appear already in the first day or two after eating an infected product.

There is a violation of the water-salt metabolism due todiarrhea, the stool becomes watery, frothy, fetid, with greens resembling "swamp mud", with a frequency of up to ten times a day, for a week or more.

The disease begins acutely, characterized by weakness, lethargy, moderate abdominal pain (the area of ​​epigastrium and navel). The abdomen is painful on palpation, there is a rumbling and noticeable swelling.

salmonella typhimurium symptoms

Salmonella Typhimurium - laboratory diagnosis

The following indicators affect the diagnosis:

  • ESR increased;
  • leukocytes with a shift to the left;

Возбудитель обнаруживается из биологических сред (feces, blood, urine, affected organs) and suspicious products by bacteriological method. The final result is usually ready by the fifth day.

When infected with salmonella typhimurium, the symptoms are as follows:

  • fever;
  • chills;
  • severe diarrhea;
  • vomiting.

Treatment

This disease can be fatal in infancy, in the elderly, as well as in persons with reduced immunity. This and dangerous salmonella typhimurium.

The treatment consists of antibiotic therapy and rehydration. Also prescribed antispasmodics, enzyme preparations, sorbents, antidiarrheals. Shown diet "Table number 4".

Therapy should take place under the strict supervision of a physician, and in severe cases, resuscitation measures are applied. From sorbents for detoxification of the body, it is advisable to use the following drugs:

  • "Enterosgelya";
  • "Liferan";
  • activated carbon;
  • "Smekty";
  • "Enterodez".

    salmonella typhimurium

With frequent, persistent vomiting,It is imperative to call an ambulance to prevent dehydration. The patient is usually prescribed Regidron. Increased temperature is reduced by antipyretic drugs.

Salmonella enterica antibiotics active against Salmonella

Антибактериальными средствами, активными в respect salmonella salmonella enterica, stand "Furazolidone", "Ciprofloxacin", "Rifaximin", "Nifuroksazid." But they can only be prescribed by the attending physician, selecting an individual dosage and taking into account the condition of the patient infected with salmonella typhimurium.

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