What is a drug substance like protamine sulfate? Instructions for its use, as well as the form and indications of this tool will be indicated below.
What is Protamin Sulfate?This solution is available in the form of a yellowish or colorless transparent liquid, intended for intravenous administration. The drug on the basis of this drug substance is of the same name and additionally contains water for injection.
The sale of "Protamine sulfate" comes inampoules, which are placed in contour cells of polyvinyl chloride film, which are packaged in cardboard packs. Also, the package contains instructions for use and an ampoule knife.
What is protamine sulfate? The instruction reports that this is a heparin antagonist (specific). 1 mg of this substance is able to neutralize in the blood of the patient about 80-115 units of heparin.
The effect of the funds in question afterThe intravenous injection comes instantly and lasts about two hours. Complexation of this drug is due to the abundance of cationic groups that bind to the anionic centers of heparin.
According to the instructions protamine sulfate in the human body forms a complex protamine-heparin, which breaks down with the release of the latter.
In case of an overdose with this remedy, blood coagulability can be significantly reduced in the patient, since the active substance of the drug in question shows a high anticoagulant activity.
What are the kinetic properties of heparinProtamine sulfate? According to experts, the pharmacokinetic characteristics of this drug substance have not been studied. Therefore, they are not represented in the instruction.
In what cases can an intravenous solution of "Protamine sulfate" be prescribed to a patient? Application of this tool is shown:
The drug "Protamine sulfate" (prescription for its purchase should be prescribed only by a doctor) is contraindicated for use in the following cases:
One can not help saying that the experience of medical use of this drug in children is limited.
During pregnancy and feeding "Protaminesulphate "can be used, but this should only be done if the expected effect of treatment significantly exceeds the likely risk for the fetus or child.
The solution should be administered slowlyintravenously by drip or jet. At the same time, the rate of administration should not exceed 5 mg per minute. A faster administration of the drug may cause the patient to have an anaphylactoid reaction.
The dosage of this medication depends on the methodits introduction. The calculated dose should be dissolved in 300-500 ml of a 0.9% solution of sodium chloride. It is strictly forbidden to administer more than 150 mg of the drug within 60 minutes.
The maximum duration of therapy is 3 days.
Can protamine sulfate cause side effects?reaction? The instruction states that in general this preparation is relatively well tolerated by patients. However, in some cases it can still cause negative effects on the part of the immune, cardiovascular and digestive systems, as well as skin:
The solution considered forintravenous administration, is incompatible with penicillins and cephalosporins. In view of the fact that it is an antagonist of low molecular weight heparins, this medication can prolong the duration and intensity of the action of nondepolarizing muscle relaxants.
An overdose of the drug may be accompanied bybleeding. This is due to the fact that the substance in question has a high anticoagulant activity. In this case, symptomatic treatment is required.
What you should know about before you enter such asolution like protamine sulfate? Experts argue that the use of this drug should be strictly controlled by a doctor who is obliged to regularly monitor the coagulability of the patient's blood.
Before the introduction of this medication it is necessary to make sure of the adequate volume of the patient's blood. This is due to the fact that hypovolemia significantly increases the risk of collapse.
Is the preparation "Protamine Sulfate" available for free in pharmacies? The recipe in Latin or Russian should be presented to the pharmacist, otherwise the medication will not be released.
Keep this facility innot accessible to children and protected from sunlight, where the temperature of the air is from 4 to 10 degrees. It should also be noted that the intravenous solution of "Protamine sulphate" should never be frozen.
Shelf life of this medication is 4 years from the date of manufacture. Do not use it after this period.
There are not a lot of analogues for the means under consideration. Intravenous solution can be replaced with such drugs as "Protamine" and "Protamine-Ferene".
As for consumer feedback,almost all of them are positive. "Protamine sulphate" is a very effective and effective remedy available to everyone. This is the opinion most patients adhere to. They argue that this medication does not allow heparin to inhibit the process of blood coagulability, improving the patient's condition with severe bleeding.
Also to the merits of this drugsubstances include its rapid and prolonged action. In addition, to achieve therapeutic effect, the patient does not need to undergo long-term treatment. The maximum period of use of this drug is three days.
