Today, infertile couples are becoming more and more, andit's very sad. If, during the examination of both spouses, there are no pathologies on the part of the reproductive system, doctors prescribe an analysis for the compatibility of partners.
What is compatibility?
Approximately 6% of all reasons for the absence ormiscarriage is infertility on immunological grounds. This means that two people are incompatible with each other, in the body of a woman antibodies are produced to the spermatozoa of a man, as a result of which they perish like alien particles. Naturally, pregnancy in this case can not occur, but even if it occurred, a fetal egg that has half a chromosome set from the father will also become alien and will be destroyed for up to three weeks.
To date, it is not completely clear whyThis happens, but it has already been confirmed that scraping, operations on the ovaries and uterus, the presence of an intrauterine device, and even inflammation may be the reason for the activation of antibodies directed at the destruction of spermatozoa.
A male organism can also have antibodies totheir own spermatozoa. This can be understood if, during the examination, the glued together and the inactive spermatozoa are visible in the microscope. It is suggested that high temperatures, injuries and scrotal surgery can provoke the formation of antibodies.
Compatibility analysis of spouses
In order to test whether two people fit together, a number of studies are carried out.
The very first compatibility test is postcoital test (Shuvarskogo-Gunnera). The essence of it is to determine the quantitylive spermatozoa in cervical mucus, taken from the vagina of a woman during the period of ovulation. A small amount of mucus is applied to a slide and examined in a microscope.
This compatibility test is not considered by all doctorsreliable, because it is necessary to conduct the examination in ovulation, while at other times the quality of the cervical mucus varies greatly and a false negative result is possible. Incorrect test can be for other reasons, for example, lack of estrogens in the body of a woman, stenosis of the cervical canal, scars on the cervix, inflammation of the cervical canal. The analysis may be inaccurate and because of oligospermia and sexual disorders in men.
In view of the large number of errors, this test should not be regarded as the main one, there are other more reliable methods of examination.
For clarification can be carried out Kurzrock-Miller's test. It is that the woman's cervical mucus connects to a slide with the sperm of another man, and the spermatozoa of a man - with the mucus of another (giving birth) a woman.
Determination of antisperm antibodies (MAR-test and latex agglutination method) Is the basic immunological assay for compatibility. It is performed in both men and women, in pairs that have a negative postcoital test. The material is sperm, mucus and blood.
There is also genetic compatibility analysis (HLA-typing), during which the level of similarity of the DNA of the mother and father is studied. In the norm of these coincidences should not be.
Nature so conceived that with the "similarity" of genesthe child simply should not be born, because with the genetic material he inherits not only the external signs, but also the predisposition to any diseases. This can be most clearly seen by looking at children whose parents are relatives. Most have physical and mental disabilities. And this is due to the inheritance of identical genes.
Therefore, if the immunological incompatibilitycan be overcome, then genetics can not be affected. Of course, any form of incompatibility brings pain and emotions to the couple, but it is worthwhile to weigh the pros and cons before deciding to part or use donor material for conception.
