But-shpa - instructions for use.

Dosage form

The drug can be produced in two forms - tablets and solution for injections.

Biconvex, round tablets, with orange or greenish tint of color. On each side of the tablet is labeled "spa".

Composition:

Substance:

• drotaverina hydrochloride - 40 mg (in 1 table).

Excipients:

• corn starch;
• magnesium stearate;
• lactose monohydrate;
• polyvidon.

But-shpa in ampoules. The instruction says that the drug solution can be designed for both intramuscular and intravenous infusions. The solution is greenish-yellow, transparent.

Composition:

Substance:

• drotaverina hydrochloride - 20/40 mg (in 1 ml or in 1 ampoule, respectively).

Excipients:

• ethanol 96%;
• sodium metabisulphite;
• water for injections.

Pharmacological action of the drug "No-shpa"

The instruction says that no-shpa is myotropicantispasmodic. The main active ingredient drotaverin is a derivative of isoquinolone and exhibits a spasmolytic effect on the smooth muscle by the inhibition of phosphodiesterase 4. Inhibition of this enzyme can lead to an increase in the content of cAMP in the blood, which can inactivate the chain of myosin kinase. It is the latter that leads to smooth muscle relaxation.

An enzyme that hydrolyses cAMP insmooth muscle cells of the myocardium and blood vessels, is an isoenzyme of phosphodiesterase 3 - this shows a rather high effectiveness of the drug as antispasmodic, because when it is used there is no pronounced effect on CCC, as well as undesirable cardiovascular events.

But-shpa is effective for smooth-muscle spasms likemuscular, and nervous etiology. In addition, regardless of the type of vegetative innervation, the drug can act on the smooth muscle structure of the biliary tract, gastrointestinal tract, vascular and genitourinary systems. But-shpa can also improve the blood supply of tissues, thanks to its vasodilating effect.

But-shpa - the testimony

It is used as a primary remedy for the following diseases:

• cholecystitis;
• cholelithiasis;
• pericholecystitis;
• cholangitis;
• papillitis;
• cystitis;
• pyelitis;
• tenesmus of the bladder;
• as well as to increase the rate of opening the cervix.

It is used as an adjuvant for the following diseases:

• gastritis;
• spasms of the cardia;
• spasms of the pylorus;
• colitis;
• enterocolitis;
• stomach ulcers;
• ulcers of the duodenum;
• dysmenorrhea;
• headache;
• strong birth pains.

Side effects of the drug no-shpa

The instruction describes all possible side effects with respect to various systems and organs.

Possible side effects of the drug on the part of the digestive tract:

• constipation;
• nausea.

Possible side effects of the drug from the side of the central nervous system:

• insomnia;
• dizziness;
• headache.

Possible side effects of the drug on the part of the CCC:

• arterial hypertension;
• tachycardia.

Other side effects:

• allergic reactions to components are possible.

Contraindications to the drug but the spine

The instruction describes the following types of contraindications:

• hepatic or renal insufficiency;
• heart failure;
• age up to 1 year;
• sensitivity to drotaverine or other substances in the drug;
• with arterial hypotension the drug should be used with caution.

Enter the drug is necessary for the patient only in the supine position, because in this case there is a risk of collapse.

Overdose with no-shpa preparation

The instruction does not have information about cases of overdose with this medication.

Drug interaction with other drugs

When used simultaneously with levodopa, no-shpa reduces its antiparkinsonian effect.