Chooses a dosage of "Amoxiclav" doctor,prescribing drug. Certain recommendations in this regard are contained in the instructions that the manufacturer applies to the medicine. There are several forms of release (tablets, substance for injection, suspension). For each of them - their own dosage and use rules.
«Амоксиклав» принадлежит к числу антимикробных means, therefore it can be applied strictly under the control of the doctor. Self-medication can cause ineffectiveness of the course, provoke the appearance of superinfection and other complications. To receive the drug showed the most pronounced results, you will need to use the medicine in the doctor's recommended form exactly as many days as the doctor will say, clearly observing the dosage and frequency of use. The doctor chooses the dosage of "Amoxiclav" based not only on the diagnosis of the patient, but also on the individual characteristics of the organism. The role is played by age, weight, diagnosis, severity of the course of the disease.
Прежде чем разбираться с дозировкой "Amoxiclave", it is worth paying attention to options sold in pharmacies. The drug is quite popular, it is produced by several pharmaceutical companies, so there are many release forms.
Quite often doctors recommend to stopon combined tablets "Amoxiclav" 250 + 125. The first figure reflects the amount of amoxicillin in one tablet, the second indicates the content of clavulanic acid. What dosage of "Amoxiclav" in this form will be prescribed by a doctor, can not be said beforehand. As a rule, several tablets are used per day. Specific volumes depend on the diagnosis, the characteristics of the patient's body.
In addition to the main components, tabletscarmellose, cellulose are present. The manufacturer in the attached documentation lists all the components of the tablets. Carefully to study them it is necessary at hypersensibility to the compounds used in pharmaceutics.
Powdered medicament forpreparation of the suspension. The drug is intended primarily for minors. They proceed by choosing the dosage of the Amoxiclav suspension 125 + 31.25, from the age of the child, the diagnosis. The first figure shows the content of the antimicrobial component, the second reflects how much in the composition of the acid that provides amoxicillin protection from the active compounds produced by microorganisms.
The second version of the drug for children -strengthened, that is, the concentration of active compounds is twice as high: 62.5 + 250 mg. For children, dosage of "Amoxiclav" in this form must necessarily be agreed with the doctor. The doctor will tell you how to dilute the powder correctly in order to keep the proportions. Excessive use can cause a negative reaction of the body, so it is important to follow the established rules.
In addition to the basic compounds, sodium citrate, saccharin and benzoate, cellulose and mannitol are also present in the Amoxiclav suspension.
For this format, the dosage is chosen"Amoxyclav" is a doctor. As a rule, the drug is used in a hospital. There are two options for producing a pharmaceutical product: 600 mg and twice as large. In the first - 500 mg of the antimicrobial component, five times less - clavulanic acid. The reinforced form contains active compounds in a ratio of 1000 + 200.
Additional components in this form of release are not used by the manufacturer. The tool is intended for intravenous infusion. The procedure is recommended under the supervision of the attending physician.
There are, in addition to the usual, reinforced optionstablets "Amoxiclav". The dosage of the active ingredient per capsule is 500 + 125 or 875 + 125. The first figure reflects how much amoxicillin is in the composition, the second describes the content of an antibiotic stabilizing element that protects it from the influence of aggressive enzymes produced by pathological microbes. As part of the preparation, the antimicrobial compound is present in the form of a trihydrate, and the acid is a potassium salt.
Manufacturer in the manufacture of medicinesapplied additional substances. They do not have pharmacological activity, but provide a means of a long shelf life, simplify its reception, increase efficiency as a whole. Applied talc and cellulose, aromatic and coloring additives, silicon dioxide and aspartame, castor oil.
In this form of tablets "Amoksiklava" dosageactive ingredients - 500 + 125 or 875 + 125. Larger amounts of amoxicillin, a smaller figure reflects the amount of acid in the capsule of the medication. In addition to the basic compounds, additional components are used. These are various coloring, aromatic compounds, talc, cellulose, silicon dioxide. The tool is quite strong, so it is important to use under the supervision of a doctor. Improper use of the drug can cause negative effects (as well as the incorrect use of "Amoxiclav" in any other form).
For each of the forms of release have their ownrules of use, dose selection. In tablet form, the drug is intended for oral use. No need to chew the drug. Tablets washed down with water. The dosage of "Amoksiklava" is chosen by the doctor, assessing the condition of the patient, the response of the organism. The duration of the course varies from 5 days to a two-week period. Allowed the use of tablets "Amoxiclav" patients older than six years. For children younger produced suspension.
The manufacturer is recommended in the instructions forthe use of "Amoksiklava" dosage for children to choose based on the weight of the child: per kilogram - about 40 mg of the antimicrobial component. The volume obtained in such calculations is divided into three steps. The format of use is optimal for patients aged 6-12 years.
If the child’s body weight is more than 40 kg,the same medication program as an adult patient is suitable. For diseases rated as light, medium, the dosage of Amoksiklava for adults is thrice daily for a 250 + 125 tablet. Between receptions do eight-hour breaks. An alternative course is twice a day with twelve-hour breaks on a 500 + 125 tablet.
If the disease is severe,The manufacturer recommended the following dosage of Amoxiclav to adults: three times with eight-hour breaks on a 500 + 125 tablet or twice a day on a 875 + 125 tablet. In the second version, the interval between use should be 12 hours. It is desirable to accurately maintain the specified time intervals, this determines the effectiveness of the course.
"Amoxiclav 2X" is intended for oral administration.use. Each capsule must be swallowed without violating the integrity of the shell. The drug is abundantly washed down with water. Means is suitable strictly for adult patients. Use, if established severe infection, severe respiratory disease. Dosage - on a tablet containing 1 g of the active ingredient, twice daily.
For a day for adults, the maximum amount of amoxicillin is estimated at 6 g. For clavulanic acid, the upper limit is 600 mg.
Correction of the dosage of "Amoksiklava" (250mg and any other variant of the content of the active components), if the patient is deficient in renal function. If the creatinine clearance is estimated at 10 ml / min and less, it is necessary to reduce the single dose and lengthen the intervals between taking the medication. If the patient suffers from anuria, the tablets are used intermittently, reaching 48 hours.
If creatinine clearance is estimated at 80ml / min and above, the medication is prescribed with eight-hour breaks between doses. With an indicator of more than 50 ml / min, you should also observe 8-hour intervals. With a value above 10 ml / min, it is recommended to use tablets with intervals of 12 hours between doses. If the clearance is 10 ml / min or less, the recommended temporary breaks are from 24 hours. The doctor chooses a specific option based on the patient's response to the drug. Incorrectly chosen frequency of doses, dosage of Amoksiklava (250 + 125 or other forms of release) can cause an adverse reaction.
Available suspension "Amoxiclav" for children.A dosage of 250 + 62.5 or 400 + 57 is chosen by the doctor. The doctor will tell you which of these two forms should be preferred, how to use the drug correctly. The powder is intended for preparation of the solution, used orally. The dosage of "Amoksiklava" for children is not allowed to exceed the limit recommended by the manufacturer. It may be unsafe. Before use, shake the medicine bottle thoroughly, making sure that all the particles have moved away from the walls, bottom. 86 ml of pure liquid are poured into two portions. After the first, second addition, you need to mix the drug. Use it using a measuring spoon. It holds 5 ml.
Dosage for children "Amoksiklava" 250 + 62,5,400 + 57 determine, focusing on weight, diagnosis, age. Up to three months the drug is used in an amount of up to 30 mg per kg of body weight. The volumes obtained by such calculations are divided into two uses. The instructions describing the dosage rules of Amoxiclav for children indicated that it is necessary to observe the twelve-hour intervals between the use of the composition.
For children over the age of three months, butweighing less than 40 kg, the dosage of Amoxiclav suspension is 250 + 62.5 or 400 + 57, taking into account that the optimal format is up to 25 mg of amoxicillin per kilogram of weight. The dose obtained in the calculations is divided into two steps, between which they can withstand twelve-hour intervals. An alternative version of the dosage of Amoxiclav suspension to children is 20 mg per kg. This dose is divided into 3 doses, between which observe the eight-hour intervals. This program is effective when the pathology is not too hard.
If the infection is severe, the dosage of the suspension"Amoxiclav" for children is calculated as 45 mg / kg. The resulting volume is divided into two steps. You can use the drug 3 times a day at intervals of 8 hours. Then, for a day, the dose is calculated as 40 mg / kg.
Manufacturer in the instructions to "Amoxiclav" ondosage writes, indicating the upper possible limits. For children per day, the permitted dose is up to 45 mg / kg of amoxicillin. Clavulanic acid in the body should receive no more than 10 mg / kg. In order not to be mistaken with the choice of volumes of the drug, it is better to show the child to the doctor beforehand. The doctor will tell you exactly which release option is suitable, what the dosage of Amoksiklava (suspension 250 mg or other format) should be.
One ampoule of "Amoksiklava" contains 30 mgthe drug, of which 25 mg is an antimicrobial compound, and the other volume falls on the stabilizing protective component. For injective use, the drug must be prepared: the contents of the ampoule are mixed with a special liquid for injections. At 600 mg of the drug should be 10 ml of liquid, twice as much - twice the dose. The solution is injected into a vein. The duration of the procedure is up to 4 minutes.
If the doctor recommended infusion into the vein,first, the drug is dissolved in the above ratios, then the substance is introduced into the solution for infusion. For 600 mg of Amoksiklava 50 ml are needed, for twice the concentration - 100 ml of additional liquid. The duration of the procedure reaches 40 minutes.
After dilution of the contents of the ampoule introductionbegin at around 20 minutes. If the procedure fails to start during this time, the medication is disposed of. The manufacturer indicates the inadmissibility of freezing the drug.
The doctor may recommend the dosage for children."Amoksiklava" tablets, in the form of powder for suspensions, but injections are rarely used. In this form of the drug is permitted primarily for persons over the age of twelve, for patients whose body weight is 40 kg or more.
Как и в правилах по дозировке суспензии "Amoksiklava" for children (250 mg and other options for release), in the instructions for the substance for injective use indicated the recommended temporary intervals between use. The manufacturer advises to make an infusion every eight hours, for one procedure using 1.2 g of the drug.
In rare cases, injections are allowed."Amoksiklava" children from the age of three. The recommended dose for such a case is 30 mg per kilogram of the body, eight-hour breaks are taken between treatments.
Sometimes the doctor recommends which one to choose.dosage for children "Amoksiklava" (125 mg of amoxicillin or other amount), accounting for the treatment of the newborn. The antibiotic can be used if a premature baby needs it. Between injections do twelve hour breaks. The dose is selected on the basis of weight, for each kg - 30 mg. It is hardly possible to achieve the desired effect, the injections are stopped, the antibiotic is prescribed orally (for example, suspension, where the concentration of amoxicillin in milligrams is 125). Dosage "Amoksiklava" chooses a pediatrician. The duration of the program reaches two weeks.
"Amoxiclav" can be used if assignedsurgical intervention, and the risk of complications associated with pathological microorganisms, is assessed as increased. In such a situation, a drug for injective administration should be used. Immediately before the use of the anesthetic, 1.2 g of the drug are injected once, if a short-term intervention is planned. If the duration of the operation is an hour or more, you should repeat the introduction after some time intervals. The maximum frequency is 4 times a day.
If the risk of septic complicationsrated high, Amoxiclav should be used for intravenous administration after completion of the procedure. Over time, you can go on oral form. The manufacturer recommends resorting to this use case, if during the operation of the patient signs of infection have been identified.
If insufficient functioning is establishedthis body, it is necessary to carefully select the dosage for the introduction of the drug into the vein. Consider the creatinine clearance. If the indicator exceeds 30 ml / min, there is no need to change the dose relative to the standard, with the parameters smaller, but more than 10 ml / min, 1.2 g of the drug is first used, after 12 hours it is twice less. Continue the course of the introduction of the drug in the amount of 600 mg. If the creatinine clearance is estimated at 10 ml / min or less, the first dose is 1.2 g, all subsequent doses are twice as low. Between injections do daily intervals.
If renal failure is found in the child in need of treatment, dosage adjustment is necessary.
It is revealed that during hemodialysis can be derived frombody up to 85% of the active ingredients. After this procedure, you can use Amoxiclav in the form of a substance for injection into a vein. There is no need to select the course features if the patient is prescribed peritoneal dialysis, since this procedure does not affect the content of the antibiotic in the human body.
In this form, tablets are intended forpre-dissolving in water. The drug is prepared immediately before use. For one tablet, take 100 ml of liquid or a little more. The prepared liquid is immediately drunk without residue. An alternative use is to pill the tablet thoroughly, then wash it down with a clear liquid without additives.
Quiktab release form is recommended for patientsolder than twelve years old. Such tablets should be consumed if the weight of the patient is at least 40 kg. On average, 2-3 tablets of the preparation are prescribed per day, containing active ingredients in the proportion of 500 + 125. The specific dosage is determined by assessing the severity of the infectious process. Between receptions it is necessary to observe equal time intervals.
The manufacturer recommends using"Amoxiclav Quiktab" before the meal. If the disease is severe, consider the release form 875 + 125. Tablets are consumed twice daily, with 12-hour intervals between doses. The duration of the course reaches two weeks. The specific duration is chosen by the doctor based on the diagnosis, the body's response to therapy.
"Amoxiclav" belongs to the group of combinedantimicrobial drugs. The main antibacterial effect is provided by the presence in its composition of amoxicillin - a penicillin antibiotic with a wide range of efficacy. The second component is clavulanic acid. The tool inhibits the activity of beta-lactamase produced by pathological microflora. Thanks to this substance, amoxicillin is not destroyed: the acid enters into strong bonds with beta-lactamase, forming complexes that do not have pharmacological activity.
Испытания показали, что амоксициллин показывает pronounced effect when infected with an extensive spectrum of pathological microorganisms. Some infectious agents are resistant to the action of amoxicillin, but Amoxiclav shows the result due to the presence of the second active ingredient, clavulanic acid. Such a complex is effective in treating infections with listerias, peptrostrepto, pepto, strepto, entero, staphylococcus, moraxella, Proteus, Klebsiella, bacteroid, clostridium, actinomycetes.
The kinetics of the main compounds is quite close to each other.to a friend, due to which there is no mutual influence of the components. Shortly after taking the drug, rapid absorption occurs, and the maximum plasma concentration is recorded on average one hour after ingestion. Using with a meal does not adjust the absorbability of compounds. The half-life of amoxicillin is estimated at an average of 80 minutes, acids - at 60-70 minutes.
It is established that both active components are capablepenetrate organic liquids. Foci of accumulation - the uterus, ovaries, middle ear, upper jaw sinuses, respiratory system, peritoneal fluid. Components can penetrate the blood-brain barrier, making it possible to use Amoxiclav in meningitis. It has been established that the substances contained in the medicine pass through the placenta and are excreted with the milk of the nursing mother.
The use of the drug in the form of a substance forinjecting in the amount of 1.2 g allows to obtain amoxicillin concentration in the blood plasma of the order of 105.4 mg / ml. For acid, this indicator is estimated at an average of 28.5 mg / l. The maximum concentration in liquid substances in the body is reached in about an hour. Both compounds enter into strong bonds with plasma proteins. Clavulanic acid binds an average of 30 percent, the antimicrobial component - 20 percent.
Acid is metabolized in the liver cells.Elimination is carried out partially with urine by the kidneys, a certain percentage through the intestines during bowel movements, and also with air masses during breathing. Antimicrobial component leaves the body with urine.
Indications for the antimicrobial drug are as follows:
"Amoxiclav" prescribed prophylacticmedicine, if septic negative effects are expected, suppurations on the background of surgical intervention. Especially important is the use of the drug, if the procedure is carried out on the heart, kidney systems, ways of movement of bile. Amoxiclav is indicated for the prevention of complications in pelvic surgery.
Antimicrobial agent can be used asan element of complex treatment of mixed infection, when anaerobic, gram-positive, gram-negative microscopic forms of life are found in the patient's body. "Amoxiclav" is indicated for infection after operations, pneumonia, abscesses, diseases of the biliary tract and ENT organs.
The tool became widespread in the practice of orthopedists, during operations on the face, interventions affecting the jaw.
Receiving "Amoksiklava" can cause adversereactions from the body. In most cases, such actions are short-lived, easily tolerated by patients. Most often occur if a person takes the drug at its discretion, without the consent of the doctor.
It is noted that up to three people out of a hundred patients suffered from nausea; a violation of the chair disturbed four out of every hundred. The incidence of dyspepsia is estimated at 1.6%.
All other side effects appear.much less frequently indicated. The manufacturer mentions that there is a risk of increased gas formation, weight loss and gastritis, and infectious and inflammatory processes in the oral cavity are possible. Sometimes due to the use of the drug, the shade of the tongue changes. With or shortly after therapy, there is a small risk of pseudomembranous colitis. The cause of the disease is the effect of toxic compounds against clostridia infection.
Известно, что «Амоксиклав» может провоцировать angioedema, skin rash, erythema, dermatitis and necrolysis. The use of the drug is associated with the risk of anxiety, may be sore and dizzy. Possible violation of the adequacy of behavioral reactions, seizure, increased activity. Some sleep disturbed, confused consciousness. Against the background of the use of Amoxiclav, there is a risk of anemia, leuko-, thrombocytopenia, agranulocytosis.
The appearance of blood elements in urine is possible,candidiasis, fever. A long course can trigger candidiasis in the mouth. There is a risk of hepatitis, jaundice, but such side effects, as statistics show, appear very rarely. The first signs can be noticed already during the course or immediately after its completion, but in a small percentage of cases they come only a few weeks after the end of therapy.
It is unacceptable to use "Amoxiclav" if the patient had: jaundice, hepatitis while taking penicillin-type antimicrobial drugs.
It is known that increasedsensitivity to active compounds "Amoksiklava". With such individual characteristics use of the drug is prohibited. You should not use the composition, if revealed too high susceptibility of other funds from the penicillin class.
No information on possible teratogenic effect.If the doctor assesses the benefits of taking Amoxiclav during pregnancy is significantly higher than the possible risks, he can prescribe this medication to the patient. In this case, the doctor explains the risks associated with the use of the drug. "Amoxiclav" during gestation, lactation prescribes strictly according to the indications in extreme cases, if there is no safer and more effective alternative.
Изготовитель в инструкции указывает:the probability of taking an excessive amount of medication is extremely small. If you use the medication in a large dose, sleep disturbances and convulsions are possible. Some patients were dizzy and headache, the condition was becoming too excited.
Efficacy in overdose shows hemodialysis. The doctor prescribes drugs for the relief of symptoms that occur in a particular case.
