Medication "Imovan" instructions for usedefines as a hypnotic, belonging to the group of ciclopirrolones. The drug has tranquilizing, hypnotic, muscle relaxant, sedative, anticonvulsant properties.
Therapeutic effect of the drug "Imovan"(the instruction indicates this) is associated with an agonist specific effect on the omega receptors (previously they were called benzodiazepine receptors of the first and second types). The drug can reduce the time to sleep and reduce the frequency of early and nocturnal awakenings, as well as increase the duration and improve the quality of sleep. The polysomnography data demonstrate that the drug “Imovan” in patients with insomnia reduces the first phase of sleep and prolongs the second, while retaining the third and fourth (deep sleep) stages and the paradoxical (fast sleep) phase. A study using the registration of the polysomnogram withdrawal syndrome did not reveal significant rebound insomnia after taking the medication for twenty-eight days. Other tests showed that when using the medication for seventeen weeks, the disappearance of the hypnotic effect was not observed.
Hypnotic "Imovan" absorbs quickly outsidedepending on the meal. In the blood plasma, by oral administration of 3.75 and 7.5 milligrams of the drug within one and a half to two hours, the highest concentrations are reached, which are approximately 30 and 60 ng / ml, respectively. Plasma proteins are unsaturated and weak (about 45%). At the level of communication with protein, the risk of interaction with other drugs is very low. From the systemic blood flow, the drug Imovan is distributed rather quickly. The instruction reports that its concentrations in breast milk are similar to those observed in plasma. The half-life of the drug unchanged when taken in recommended doses is an average of five hours. The drug is mainly excreted in the form of metabolites in the urine (about 80%) and feces (about 16%).
Medication "Imovan" instruction showsused in the treatment of situational, transient, chronic insomnia in adults. In particular, it is used for difficulties in falling asleep, early and nocturnal awakenings.
The drug comes in the form of white coatedfilm coated oval tablets with a risk on one side. One unit of the product contains an active component - zopiclone - in the mass of 7.5 milligrams. Imovan tablets also contain sodium carboxymethyl starch, titanium dioxide, calcium hydrogen phosphate dihydrate, magnesium stearate, lactose monohydrate, wheat starch, and hypromellose.
Oral medication shownjust before bedtime. If possible, therapy should be short-term and not exceed four weeks, including a period of reduced dosage. To take the drug for a longer time than prescribed by the instruction, is allowed only after the evaluation of the patient's condition by a specialist. You should always start therapy with the minimum effective dose, increasing it if necessary, but you can not exceed the maximum allowable dose. For transient insomnia (for example, caused by a change in location during the trip), the course of treatment does not exceed two to five days. With situational insomnia, it is two to three weeks. In case of chronic insomnia, long-term therapy is required, its duration is determined by the doctor.
Суточная доза для людей младше 65-ти лет – 7,5 milligrams. Elderly patients (over 65) and those who have abnormal liver function or moderate respiratory failure are prescribed 3.75 milligrams per day. Taking medicine in the mass of more than 7.5 milligrams per day is allowed only in extreme cases. Therapy of patients with renal failure, despite the fact that in this case there was no accumulation of the drug and its metabolites, it is necessary to start with a daily dose of 3.75 milligrams.
About the drug "Imovan" reviews are morepartly positive, it is often well tolerated. But almost all patients note that after taking the medicine, a bitter taste remains in the mouth. Some people talk about the appearance of headache, dizziness with the use of sleeping pills. Among the possible negative effects should also be noted muscle hypotension, residual drowsiness after waking up, diplopia, asthenia, decreased libido. There is a risk of developing digestive disorders: nausea, dyspepsia, dry mouth. Sometimes there are skin reactions, such as rashes and itching, in very rare cases - anaphylactic reactions, angioedema. Individual patients after taking sleeping pills have hallucinations, depressive state, nightmares, problems with coordination of movements, aggressiveness, irritability, depressed mood, walking in a dream, inappropriate behavior (can be observed in combination with amnesia). Even when used in therapeutic doses of tablets "Imovan" (instruction warns about this), mental and physical dependence can develop.
In some people, after cessation of therapydrug develops withdrawal syndrome. Its symptoms can be different, most often they manifest as anxiety, confusion, rebound insomnia, tachycardia, irritability, tremor, headache, delirium, excessive sweating, nightmares, tachycardia, agitation, hallucinations. In very rare situations, convulsive seizures occur.
People with hypersensitivity to ingredientsmeans "Imovan" should refuse to use it. Also, no sleeping pills are prescribed for patients with severe pseudo-paralytic myasthenia, severe liver failure (with the risk of encephalopathy), severe sleep apnea, and severe respiratory failure. The drug is contraindicated at the age of eighteen. For people with a history of drug, alcohol, drug addiction, the drug is prescribed with caution, as in this case there is an increased risk of increased dependence or abuse.
Take a sleeping pill "Imovan" for pregnant andlactating women are not recommended. When using the drug in the third trimester, the newborn can develop such negative effects as hypotension, respiratory depression, hypothermia. Women planning or suspecting pregnancy should stop taking the medication.
Overdose is usually manifested by symptoms.CNS depression in varying degrees: from simple drowsiness to coma (depending on the dose taken). In mild cases, apathy, drowsiness, confusion, in more serious cases - lethargy, respiratory depression, ataxia, hypotension, coma. It rarely happens atrioventricular block. Overdose does not pose a threat to life if the intake of sleeping pills is not combined with the use of other medications that depress the central nervous system or alcohol. Also, symptoms of overdose can be aggravated if the patient’s general condition is weakened or there are concomitant diseases. In such cases, even fatal outcome is possible (extremely rare). When taking the drug in excessive doses, symptomatic and supportive hospital treatment is indicated. In this case, the most attention should be paid to cardiovascular and respiratory functions. Measures such as the use of activated carbon and gastric lavage will be effective only if they are carried out shortly after the use of the drug "Imovan".
Дженериками данного снотворного являются такие drugs like Somnol, Thorson, Relaxax, Piklodorm and others. As a rule, they are cheaper than the original, but at the same time are less effective.
As mentioned earlier, taking sedativesmeans, including the drug "Imovan", may entail the development of psychological and physical dependence. The risk increases with long-term treatment and taking sleeping pills in high doses, with the abuse of alcohol, psychotropic substances, and also in the presence of anxiety. If, with the appearance of physical dependence, the therapy with a drug is abruptly discontinued, the withdrawal syndrome described above may develop. To avoid this, you need to reduce the dose of the drug gradually. Two rules can be used to prevent the risk of such side effects as anterograde amnesia: you should drink a pill just before bedtime (do not allow a long time between using the medicine and going to bed) and sleep at least six hours (do not interrupt sleep earlier than after six hours after falling asleep). The drug is not indicated for the treatment of depression and may even mask their symptoms.
Simultaneous reception of sleeping pills "Imovan" andalcohol can lead to increased sedation. In addition, you can not take drugs along with treatment with drugs that depress the central nervous system: barbiturates, antidepressants with sedative effects, tranquilizers, antipsychotics, antitussives, anesthetics, narcotic analgesics, antiepileptic drugs with central action. In case of their joint use, the inhibitory effect on the central nervous system may increase. Also, do not drink Imovan pills with drugs containing trimipramine, because the plasma concentration of the latter and its effect will be reduced. Taking a sleeping pill with buprenorphine increases the risk of respiratory depression (the outcome can even be fatal).
The drug is sold in most pharmacies.Sleeping pills available on prescription. Some people who want to buy medicine without a prescription, use the services of an online pharmacy. However, it should be remembered that in this case you risk to purchase low-quality, fake or expired goods.
