Prednisolone is a semisynthetic glucocorticoida drug based on hydrocortisone. That is, it is a means with a high degree of biological activity that allows the use of Prednisolone injection in clinical situations. For example, when providing immediate assistance in emergency conditions.
Anti-allergic, anti-inflammatory,immunosuppressive action, the ability to increase the sensitivity of beta-adrenergic receptors (these are proteins of the outer cell membrane that recognize and bind the synthetic analogues of catecholamines with adrenaline and noradrenaline) to endogenous catecholamines (i.e., active substances that function as chemical "control" molecules (neurohormones) and mediators intercellular interactions) are the main functions of the drug Prednisolone. Ampoules for injection are issued in a volume of 25 mg.
Urgent conditions, such as acuteallergic reactions, thyrotoxic crisis, asthmatic status in bronchial asthma, shock not responding to standard therapy (surgical, burn, toxic or anaphylactic, traumatic or cardiogenic), acute renal or hepatic insufficiency, acute adrenal insufficiency, are an indication for the use of the drug "Prednisolone" .
Уколы назначаются также при ревматических diseases (rheumatoid arthritis or systemic lupus erythematosus), acute hepatitis and cirrhosis of the liver, bronchial asthma, as well as to reduce inflammation and prevent the appearance of scarring of tissues and blood vessels during poisoning with cauterizing fluids.
Дозировка и продолжительность курса лечения determined by the doctor individually, depending on the severity of the disease and indications for the drug "Prednisolone." The injections are administered intravenously by means of droppers (first jet, then drip) or by intramuscular injection if intravenous injection is not possible. After the acute condition has been stopped, prescribe Prednisolone in oral tablets. At the same time, the dosage gradually decreases. If the course of treatment is long, then you should not stop therapy suddenly.
This drug is effective, but it hasenough contraindications and side effects. First about the contraindications of the drug "Prednisolone". The injections are not applied even for vital signs, if there is intolerance or hypersensitivity to the constituent components. The drug should be administered with caution in cases such as recent or existing infectious diseases of the viral nature, gastrointestinal diseases, the vaccine period (as well as eight weeks before and two weeks after vaccination), immunodeficiency states.
With cardiovascular, endocrinediseases, severe chronic hepatic or renal failure, systemic osteoporosis, caution should also be taken with prednisolone. The injections during pregnancy, especially in the first trimester, as well as children in the period of growth, are applied only according to vital signs and strictly under the supervision of the attending physician. If the drug is prescribed during lactation, breastfeeding should be stopped.
Among the side effects of prednisolone is a decreasethe ability of the body to use glucose as a source of energy, suppression of adrenal function, steroid diabetes, increased intracranial pressure, steroid duodenal ulcer and stomach, increased blood pressure, bradycardia (sometimes until cardiac arrest), increased calcium excretion, delayed sexual development in children, trophic changes cornea. And this is not all the side effects. A complete list must be read in the instructions for use of the drug Prednisolone.
