The drug "Terbinafine" is an antifungal drug. Produced in the form of tablets for internal use, gel, ointment, spray, cream, solution for external use.
The drug is able to exert inhibitory andThe overwhelming effect on the biosynthesis of sterols formed in the early stages in fungal cells. The mechanism of action of the agent is based on the inhibition of the enzyme squalene epoxidase, located in the cell membranes of the fungus. As a result of depression, ergosterol deficiency occurs, and squalene accumulates inside the fungal cells, which leads to their destruction.
At low concentrations, the drug has an antifungal (fungicidal) effect against dermatophytes, yeast microorganisms and other dimorphic fungi.
Indications for taking Terbinafine
Reviews of doctors and the instruction give information aboutthe need to use the drug during the treatment of onychomycosis caused by dermatophytes, dermatomycosis of the scalp, legs, feet, trunk. Medication is prescribed for skin infections that are caused by candida fungi, in cases where the severity, general prevalence and location of lesions determine the advisability of treatment.
Contraindications to taking Terbinafine
Reviews of doctors say about inadmissibilityuse of the drug with increased sensitivity to terbinafine hydrochloride - the main active substance - and other components. It is not recommended treatment during lactation of the baby.
Side effects of Terbinafine
Reviews of many patients indicate the presencevarious negative manifestations from taking the medicine. The list of side effects can include urticaria, anaphylactic deviations, nausea, dyspnea, a decrease in pressure, dizziness. As a result of treatment, skin reactions, angioneurotic shock, toxic epidermal necrolysis, photosensitivity may appear. Therapy can be associated with the appearance of heartburn, vomiting, a feeling of heaviness in the stomach, the accumulation of gases in the intestine (flatulence); In addition, there may be a disturbance and a temporary breakdown in taste sensations. Possible development of agranulocytosis, thrombocytopenia or neutropenia in the treatment with the drug "Terbinafine".
The doctors' comments also indicate the possibility ofthe appearance of headaches, fatigue, paresthesia (impaired skin sensitivity), reducing overall sensitivity. Side effects also include pain in the joints (arthralgia), muscle pain (myalgia), menstrual irregularities, hair loss (alopecia), activation of psoriasis.
The use of the drug "Terbinafine" (tablets)
Отзывы о приеме медикамента рекомендуют следующие methods of application and dosage. The drug in tablets is taken after a meal in all cases. Children older than three years are recommended a daily dose of 62 to 250 mg, depending on the body weight. With dermatomycosis, the course of treatment is a month and a half, with candidiasis of the skin, dermatomycosis of the trunk, mycosis of the scalp, the pills are taken within four weeks. With onychomycosis, stop treatment is long (3 months), with onychomycosis the duration of therapy is reduced by half.
Patients with a reduced rate of nail growth may need a longer treatment.
The use of the drug "Terbinafine" - ointment
Reviews on the use of ointments suggestnext treatment. External means a thin layer put on sites of defeats and adjoining areas of a skin, slightly them rubbing. Ointment is used up to twice a day. The duration of therapy depends on the severity of the disease and ranges from two weeks to a month.
