Creatinine is a substance excreted in eachorganism and participating in energy metabolism. Creatinine is produced in the muscle tissue, and then enters the blood. Its content is caused by the volume of muscle mass, so the rate of creatinine in the blood is lower in women than in men, because the female predominant fat mass rather than muscle.
The amount of creatinine in the blood plasma can not change dramatically due to the fact that the muscle mass is growing quite slowly.
The average creatinine level in the blood of womenis 43-81 μmol / l. The limits of creatinine in men: 63-107 μmol / l; in infants 0-12 months - 46-104 μmol / l; in children from one year to 15 years - 24-62 μmol / l.
Elevated creatinine may be found in people who eat many animal fats and proteins. If the cause is this, then urine and blood creatinine will be elevated simultaneously.
Creatinine may increase with a sharp increasephysical exertion, serious muscle injuries, dehydration, kidney failure, radiation sickness, as well as intoxication of the body with antibiotics, barbiturates and other drugs with toxic effects.
Reduced creatinine may be in the first twotrimesters of pregnancy, with severe starvation with a strong loss of body weight, nutrition only plant products, muscle dystrophy, against the background of treatment with certain medications.
Creatinine with urine is excreted by the kidneys.If its content does not meet the standards, you can suspect kidney disease. In acute renal failure and pyelonephritis, creatinine is always elevated and its level continues to grow rapidly.
Norm: men - 8,7-17,6 mmol; women: 7.2-15.8 mmol.
With urine, all creatinine should be excreted, about two grams per 24 hours. The norm of creatinine in the blood of women and men is a more accurate indicator compared with the norms of its content in urine.
- People going through the examination for reasons of suspicion of nephrologic diagnoses or having problems with the kidneys are sent for analysis;
- when examining a person for kidney donation;
- in the treatment of drugs that have a toxic effect on the kidneys.
The norm of creatinine in the blood of women and menis determined with the help of a sample of Reberg, it also allows you to determine its level in the urine. Before taking these tests, you need to stop taking medications such as cortisol, thyroxine, corticotropin. Preparation for analysis consists in rejecting protein food 10 hours before blood donation.
The examination begins with the fact that the patientdrank half a liter of water and accurately recorded the time of urination. After that, after half an hour, blood is drawn from the vein, after another 30 minutes the urinalysis is collected. To ensure that the result was the most reliable, personal data are taken into account: age, height, weight, lifestyle of the patient.
If the level of creatinine is increased, then first of all you need to visit a nephrologist.
