The drug "Cordaflex" refers to blockerscalcium channels. This matte tablets, which are covered with a coating of yellowish color. They have a characteristic but faint smell, biconvex and round. These tablets contain 10 mg (in one piece) of the active substance nifedipine. There is another form of release, namely, pills of prolonged action. Their color is licky-purple, and the active substance in one piece is already 20 mg. In addition, the drug "Cordaflex" (instruction for use confirms this) contains and auxiliary substances.
What is its pharmacological effect?It is a blocker of calcium channels, it is able to have an antianginal and antihypertensive effect. Regarding the drug "Cordaflex" instructions for use informs that it can reduce spasm, and also expand peripheral and coronary arterial vessels, reduce afterload. The blood supply of the myocardium zones, which are ischemic, is improved. The active substance of this agent increases the renal blood flow.
The clinical effect after taking this drug (meaning the form of long-acting tablets) develops in about 20 minutes, and its duration is up to 24 hours.
Consider the pharmacokinetics.With regard to absorption, then after ingestion of the described drug is almost completely and fairly quickly absorbed from the digestive tract. And the maximum concentration in the blood (in the case of a dosage of 10 mg) will be reached about one hour after admission. The drug is able to penetrate the placental barrier, in addition, it is excreted together with breast milk. If you take a pill with a dosage of 10 mg, then nifedipine will be excreted from the body in 2 hours. In the case of the form of the drug with prolonged action, this period significantly increases - up to 16.9 hours. It is excreted in the urine (approximately 70 percent), and the remaining 30 with feces and bile.
Dosage regimen of the drug "Cordaflex" instructionon application describes this: it is set individually. It all depends on the patient's response to therapy and the severity of the particular disease. Three times a day, adults take pills, which are coated, that is, 10 mg each. The maximum dose allowed for 24 hours is 40 mg. If there was a hypertensive crisis or an attack of angina, the tablet should be chewed and washed with water to strengthen its effect. The patient may also need exchange therapy. In this case, the administration of tablets with prolonged action is recommended in a dosage of 20 mg in only two times in 24 hours. For elderly patients, the amount of the drug is halved. It is worth noting that you can not chew tablets of prolonged action, just drink it with water, regardless of meals. But the drug in a dosage of 10 mg taken before eating.
As for the side effects of the facility"Cordaflex" (the reviews confirm this), there are a lot of them, not only from the central nervous system, urinary, endocrine, digestive, cardiovascular systems, but also the hemopoiesis system, as well as the musculoskeletal system. Allergic reactions are also possible.
Indications for taking the drug "Kordaflex"(instructions on how to use this report) are: arterial hypertension, Raynaud's syndrome, IHD. A list of conditions and diseases in which the drug is prohibited is large enough: cardiogenic shock, mitral or aortic stenosis, myocardial infarction (acute stage), severe heart failure, the first trimester of pregnancy, the period of breastfeeding, adolescent and, of course, children's age. You can not use the drug and at the same time continue to manage any vehicles. The analogue of this drug is the drug "Cordaflex RD".
