The drug "Prestans" (tablets) isa fixed combination of two fairly well-known drugs, "Amlodipine" and "Prestarium A." Today, according to experts, this tool is one of the most fruitful. This antihypertensive combination allows not only effective but also safe, in adequate time to lower blood pressure in patients with varying degrees of arterial hypertension.
According to the manufacturer, the drug "Prestan" is successfully used in more than thirty countries around the world.
Both substances in the drug contribute torestoration of elasticity and softness of the vessel wall. The drug prevents, thus, the development of stroke and heart attack. Along with this, studies have shown a good tolerability of the drug. The manufacturer claims that after taking the remedy there is no puffiness, headache, cough, which is explained by the properties of the active substances.
The medicine is available in four combinations.So, the preparation "Prestanz" 10/5, 5/5, 10/10, 5/10 is issued. In combination, the first figure indicates the content of perindopril arginine (drug "Prestarium A"), and the second - amlodipine benzylate. The dosage is indicated in milligrams.
The drug "Prestans" instructions for use recommends with IHD and hypertension.
Included in the composition of perindopril is used fortreatment of high blood pressure of varying severity. When taking the remedy, a decrease in both systolic and diastolic pressure is noted. Perindopril helps to reduce the overall peripheral resistance in the vessels, this leads to a decrease in blood pressure, as well as improvement of peripheral blood supply without changes in the frequency of cardiac contraction. When taking the drug, the kidney blood flow increases. At the same time, the glomerular filtration rate is unchanged.
The active component of perindopril has a vasodilating property, it helps to reduce hypertrophy in the left ventricle.
Антигипертензивное воздействие средства "Prestans" (instructions for use testifies to this) reaches a therapeutic maximum after a single dose after 4-6 hours and lasts no less than 24 hours. At the same time, a decrease in blood pressure is observed almost immediately after administration.
A persistent therapeutic effect is observed after one month from the first application. The patient's condition is not accompanied by tachycardia. When discontinuing treatment, there is no withdrawal syndrome.
The component of amlodipine inhibits transmembranetransition into cells of smooth muscles in the walls of blood vessels and cardiomyocytes of calcium ions. The substance has a direct effect on the smooth muscle cells. The ability of amlodipine to provoke the expansion of peripheral arterioles is proved, reducing the overall peripheral vascular resistance. At the same time, the heart rate remains unchanged, and the need for oxygen in the myocardium does not increase.
To contraindications to the use of drugs"Prestanza" instructions for use include hereditary lactose intolerance, glucose-galactose malabsorption, lactase deficiency, age up to eighteen years, renal failure, hypersensitivity to the components. The drug is not prescribed for severe arterial hypotension, angioedema in history, unstable angina, obstruction of the exit route in the left ventricle.
The drug "Prestans" instructions for use prohibits the appointment during pregnancy.
The drug is usually prescribed a pill once a day. It is advisable to take the remedy in the morning, before breakfast. The dosage of the drug is set individually.
Before using the medicine "Prestans" you need to consult with your doctor.
