Do you know what helps "Nize" (pills)? If you do not possess such information, we will present it in the materials of this article.
About what helps "Nize" (tablets), webelow. The active ingredient of this drug is nimesulide. Also in its composition it includes such components as microcrystalline cellulose, aspartame, calcium phosphate, colloidal silicon dioxide, corn starch, magnesium stearate, sodium carboxymethyl starch, pineapple flavor and talc.
On sale, the drug in question comes in blisters of 10 tablets packed in packs of cardboard.
Before answering the question of what helps "Nize" (tablets), you should tell us how this drug works.
According to the instructions, this is an NSAID, which is selectiveinhibits COX-2, that is, an enzyme involved in the synthesis of prostaglandins - mediators of pain, inflammation and edema. In addition to anti-inflammatory properties, the drug in question exhibits antipyretic and analgesic effects.
It is impossible not to say that this medicationinhibits (reversibly) the formation of prostaglandin E2 in the ascending pathways of the nociceptive system and the focus of inflammation, as well as in the ways of impulses (pain) in the spinal cord.
The drug "Naise", analogues of which are listedbelow, reduces the concentration of prostaglandin H2 (short-lived), from which, under the influence of prostaglandin-isomerase, prostaglandin E2 appears. Reducing the concentration of the latter leads to a decrease in the degree of activation of the receptors of the EP type (prostanoid), which is expressed in anti-inflammatory and analgesic effects.
It should also be noted that in a smallthe drug under consideration affects COX-1. Under physiological conditions, it almost does not prevent the occurrence of prostaglandin E2 from the arachidonic acid. This reduces the number of side effects of the drug.
The drug "Naise" is able to suppress aggregationthrombocytes. This occurs by inhibiting the synthesis of thromboxane A2 and endoperoxides. In addition, it inhibits the release of histamine, and also reduces the degree of bronchospasm, which was caused by the effects of acetaldehyde and histamine.
Specialists have proven that nimesulide is goodsuppresses the synthesis of urokinase and interleukin-6, preventing the destruction of cartilaginous tissues. In addition, it inhibits the synthesis of metalloproteases, preventing the destruction of collagen and proteoglycans.
According to the instruction, by reducing the activity of myeloperoxidase, the drug in question exhibits antioxidant properties and slows the formation of products of (toxic) decay O2. It interacts with glucocorticoid receptors and activates them, which contributes to the enhancement of anti-inflammatory action.
After ingestion, the anesthetic "Naise" is absorbed from the intestine. Eating food reduces the rate of absorption of the drug, but does not affect its degree.
The peak concentration of nimesulide in the blood is reached after 2.6 hours. Its connection with proteins reaches 95%.
This drug penetrates into all tissues of the female genital organs. Furthermore, it is found in an acidic medium focal inflammation and synovial fluid.
Metabolism of nimesulide is carried out in the liver. Its half-life is 5 hours. It is excreted mainly by the kidneys, and also along with the bile.
What helps "Nize" (tablets)? This means is prescribed for:
Also it should be noted that the "Nyz" helps the temperature well. This drug is used for fever of various origins, including inflammatory and infectious diseases.
The drug "Naise" during pregnancy is prohibited. Also it should not be used when:
With special care this drug is prescribed for type 2 diabetes, arterial hypertension and cardiac insufficiency.
The medicament in question in the form of tablets is administered only orally. Adult patients are recommended to take 100 mg twice a day. The maximum dosage of the drug per day is 400 mg.
As for dispersible tablets,than to take such a medicine, it should be previously dissolved in 5 ml of ordinary water (in 1 dessert spoon). Use this remedy at the end of the meal or after eating.
Children do not prescribe the drug in tablets. For them, there is another form of medication - a suspension. It is recommended to take it at the age of two years.
The drug "Naise", the dosage of which was presented above, can cause such undesirable reactions as:
What are the symptoms of a largethe number of tablets "Nyz"? The dosage of this medication should be determined by the attending physician. If the medicine is accidentally swallowed (in large quantities), the patient may develop the following symptoms: convulsions, increased blood pressure, irritation of the gastrointestinal mucosa, impaired renal function, hepatic insufficiency and respiratory depression.
To eliminate such conditions, the patient is washed with a stomach, prescribed activated charcoal and conducts symptomatic therapy.
With simultaneous oral administration of the drug"Naiz" diuretics "Digoxin" "phenytoin", antihypertensive agents and lithium agents, as well as other NSAID, cyclosporine, anticoagulants, methotrexate, hypoglycemic medication (oral), the patient may manifest drug interactions (due to the competing agents data for binding to proteins).
You can replace the drug under consideration with such medications as Nimulide, Aponil, Arkoksia, Mesulid, Meloksikam, Nimesil, Movalis, Nimesulid, Denebol, Nimika.
Most of the consumer feedback onthe preparation in question is of a positive nature. According to their opinion, "Nize" is quickly relieved of pain, and the drug is also used as a highly effective anti-inflammatory drug. Although some patients claim that this medication has one significant disadvantage. It very often causes such adverse reactions as dizziness, weakness and problems with the digestive system. In this case, doctors recommend to replace the drug with a similar remedy.
