Medication "Celebrex" instructions for usecharacterizes as a non-steroidal anti-inflammatory agent with pronounced antipyretic and analgesic properties. The effect of this drug is to suppress the synthesis of prostaglandins due to oppression of COX-2. At the same time, "Celebrex" tablets, the instruction for their use confirms this, to a much lesser degree than other non-steroidal anti-inflammatory drugs, contribute to the development of so-called gastroduodenal ulcers. As for the pharmacokinetics of this drug, its highest concentrations are noted one hundred twenty minutes after use, and the half-life is about eight to twelve hours.
The main contraindications to the appointment of suchan anti-inflammatory agent, such as Celebrex, is an individual intolerance to celecoxib, an allergic reaction to sulfonamides, and a condition after aorto-coronary bypass surgery. In addition, do not take this medication for people suffering from bronchial asthma, inflammatory bowel disease or heart failure.
In the case of hypersensitivity toAcetylsalicylic acid also should not begin taking tablets "Celebrex." The doctors' testimonies testify to the undesirability of their use by people with severe form of renal or hepatic insufficiency. The list of contraindications includes the age of up to eighteen years, the period of gestation, lactation period, ischemic disease, gastrointestinal bleeding, peripheral arterial disease and peptic ulcer. With extreme caution to take the drug "Tselebreks" instruction for use advises in case of violations in the cardiovascular system, hyperlipidemia, dyslipidemia and diabetes. People with cerebrovascular diseases, physical illnesses, peptic ulcer and predisposition to swelling and fluid retention should also refrain from using this anti-inflammatory drug.
A list of possible adverse reactions associated withthe reception of "Celebrex" tablets includes tinnitus, thrombocytopenia, cardiac rhythm disturbance, alopecia and hypertension. In addition, some patients complain of increased anxiety, coughing, upset of the stool, nausea, dysphagia, diarrhea and angioedema.
