The drug "Ketotifen" refers to the group of cycloheptathiophenone agents, which have a pronounced antihistamine effect.
The mechanism of action of the drug "Ketotifen"
Reviews of doctors indicate that the drug is slowing downthe release of mast cells from histamine, blocks histamine receptors, inhibits phosphodiesterase enzymes. When using the drug, the level of cyclic adenosine monophosphate in mast cells increases. The medication is involved in suppressing the effects of thrombocyte-activating factors. The medicine does not produce relief of asthmatic attacks, but only prevents their occurrence, reduces intensity and duration, in some cases, their complete disappearance occurs. The drug has a positive effect on sputum production.
Composition and pharmacokinetics of the drug "ketotifen"
Reviews of pharmacists and instructions for use indicate the presence of the main active ingredient in the drug - ketotifen fumarate.
The drug is almost completely absorbed.by the body. The bioavailability of the drug is 50 percent, the tool overcomes the blood-brain barrier. Metabolism occurs in the liver, the drug is excreted in the form of metabolites by the kidneys. The main part of the substance goes through the kidneys within two days.
Indications for taking Ketotifen
Reviews and recommendations of doctors characterizemedicine as an effective remedy for the treatment of atopic asthma and dermatitis, hay fever, allergic rhinitis and conjunctivitis, as well as urticaria.
The drug is made in the form of 1 mg tablets and Ketotifen syrup.
Children older than three years prescribed 1 mgmeans in any form 2 times a day. Adults should take the same amount of the drug in the morning and evening. If necessary, double the dose. The medicine is consumed while eating inside. The duration of therapy is 3 months. Cancellation of treatment produced within two weeks.
Contraindications and side effects from taking the drug "ketotifen"
Patient reviews indicate suchnegative phenomena like dizziness, drowsiness, slow reaction, feeling tired. When using the drug, a sedative effect is observed, sleep can be disturbed, anxiety, nervousness in children occurs. In addition, patients feel dry mouth, their appetite increases, vomiting or nausea and constipation may begin. Side effects include thrombocytopenia, allergies, weight gain.
The drug "ketotifen", syrup and tablets, is not recommended for use during pregnancy and during lactation. Prohibited medication for children up to three years, as well as with hypersensitivity to the components.
The drug "ketotifen": special instructions
It is undesirable to make a sharp cancellation of the drug to patients with bronchospastic syndrome and bronchial asthma. Treatment is stopped smoothly, reducing the dosage for two to four weeks.
Patients who are sensitive tosedation, medication prescribed in small doses. The medication is not intended for the treatment of asthma attacks. With the joint appointment of hypoglycemic agents should be monitored for the number of platelets in peripheral blood.
The drug affects the ability to drive vehicles and mechanisms, so you should refrain from these works during treatment.
The tool enhances the effects of sleeping pills, ethanol and antihistamines, and in combination with hypoglycemic drugs increases the risk of thrombocytopenia.
Similar medical effects have the drugs "Zaditen", "Ketof", "Stafen", "Positana".
